Nobuko Koshikawa Selected Research

tetraphenylporphine sulfonate (TPPS)

4/2022	Suppression of non-small-cell lung cancer A549 tumor growth by an mtDNA mutation-targeting pyrrole-imidazole polyamide-triphenylphosphonium and a senolytic drug.
10/2021	A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation.
6/2021	A PI polyamide-TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation.

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Nobuko Koshikawa Research Topics

Disease

20	Neoplasms (Cancer) 04/2022 - 07/2003
8	Neoplasm Metastasis (Metastasis) 12/2021 - 10/2003
6	Hypoxia (Hypoxemia) 01/2010 - 09/2002
3	Lewis Lung Carcinoma 10/2021 - 10/2003
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2022 - 01/2021
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021 - 01/2020
2	Carcinoma (Carcinomatosis) 10/2008 - 10/2003
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 03/2021
1	Obesity 01/2021
1	Weight Loss (Weight Reduction) 01/2021
1	Body Weight (Weight, Body) 01/2021
1	Inflammation (Inflammations) 01/2020
1	Neuroblastoma 01/2019
1	Colorectal Neoplasms (Colorectal Cancer) 01/2016
1	Colonic Neoplasms (Colon Cancer) 04/2015
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 04/2015
1	Burkitt Lymphoma (Burkitt's Lymphoma) 04/2015
1	Osteosarcoma (Osteogenic Sarcoma) 01/2014
1	Fibrosarcoma 08/2007
1	Breast Neoplasms (Breast Cancer) 07/2003
1	Brain Neoplasms (Brain Tumor) 07/2003

Drug/Important Bio-Agent (IBA)

11	Mitochondrial DNA (mtDNA)IBA 04/2022 - 09/2002
10	Nylons (Nylon)IBA 04/2022 - 01/2014
6	PyrrolesIBA 04/2022 - 01/2014
6	imidazoleIBA 04/2022 - 01/2014
5	Messenger RNA (mRNA)IBA 01/2020 - 10/2003
4	Proteins (Proteins, Gene)FDA Link 04/2015 - 10/2003
3	tetraphenylporphine sulfonate (TPPS)IBA 04/2022 - 06/2021
3	Pharmaceutical PreparationsIBA 04/2022 - 01/2010
3	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 09/2008
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2005 - 09/2002
2	triphenylphosphoniumIBA 04/2022 - 12/2021
2	NucleotidesIBA 10/2021 - 11/2017
2	DNA (Deoxyribonucleic Acid)IBA 03/2021 - 01/2019
2	NADH DehydrogenaseIBA 01/2021 - 11/2017
2	Oxygen (Dioxygen)IBA 12/2005 - 09/2002
1	SenotherapeuticsIBA 04/2022
1	Histones (Histone)IBA 12/2021
1	Adenosine Triphosphate (ATP)IBA 12/2021
1	LeptinIBA 01/2021
1	Adiponectin ReceptorsIBA 01/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021
1	AdipoRonIBA 01/2021
1	ChemokinesIBA 01/2020
1	Interleukin-33IBA 01/2020
1	CytokinesIBA 01/2020
1	Small Interfering RNA (siRNA)IBA 01/2020
1	1-methylimidazoleIBA 01/2018
1	Fluorescein (Funduscein)FDA LinkGeneric 01/2018
1	Alkylating AgentsIBA 01/2016
1	Codon (Codons)IBA 01/2016
1	Adenine FDA LinkGeneric 04/2015
1	Transcription Factors (Transcription Factor)IBA 01/2014
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 11/2009
1	Histone Deacetylases (Histone Deacetylase)IBA 11/2009
1	Protein Kinase CIBA 11/2009
1	Phosphatidylinositols (Phosphatidylinositol)IBA 08/2007
1	3-methyladenineIBA 08/2007
1	DNA Polymerase iotaIBA 12/2006
1	Deferoxamine (Desferal)FDA LinkGeneric 12/2006
1	cobaltous chloride (cobalt(II)chloride)IBA 12/2006
1	Diphtheria ToxinIBA 12/2005
1	Carrier Proteins (Binding Protein)IBA 12/2005
1	Erythropoietin FDA Link 12/2005
1	EndostatinsIBA 07/2003
1	Factor VIII (Coagulation Factor VIII)IBA 07/2003

Therapy/Procedure

4	Therapeutics 04/2022 - 12/2005
2	Drug Therapy (Chemotherapy) 04/2015 - 12/2005
1	Fat-Restricted Diet (Diet, Fat Restricted) 01/2021
1	Radiotherapy 12/2005